The Wilmslow branch of the Royal Bank of Scotland will be closing.
NatWest has announced the closure of 32 branches, including 21 of its NatWest banks and 11 Royal Bank of Scotland branches - including the one on Water Lane.
A NatWest spokesperson said: "As with many industries, most of our customers are shifting to mobile and online banking, because it's faster and easier for people to manage their financial lives.
"We understand and recognise that digital solutions aren't right for everyone or every situation, and that when we close branches we have to make sure that no one is left behind.
"We take our responsibility seriously to support the people who face challenges in moving online, so we are investing to provide them with support and alternatives that work for them."
The Royal Bank of Scotland closed their Grove Street branch in August 2015.
We are currently awaiting confirmation from Nat West regardig when the Water Lane branch will close.